My current neighborhood is, well, very distinct. The plus sides: it has funky bars and eateries that people from all over the city flock to (and then flee from), it is relatively centrally located, and has lots of nearby green space (Buena Vista Park, Panhandle, Alamo Square, Golden Gate Park). The down side: noise, grime, crime, open air dealing . . . and finally, hipsters. Lots and lots of hipsters. (Almost as many as the Mission).
Yeah, they do make sense in cities with no hills...or on velodrome tracks. Hmmm. Now I know why the hipsters live in the Mission - it's the only flat land for miles.